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A new study published in The BMJ found a link between systemic and inhaled glucocorticoids— medications commonly taken for asthma and chronic obstructive pulmonary disease (COPD)— and structural and volume changes in brain gray and white matter. Results are based on a cross-sectional study conducted among 779 individuals who took the medications and 24,106 controls enrolled in the UK Biobank between 2006 and 2010. Of the patients included in the biobank, 222 used systemic glucocorticoids and 557 took inhaled glucocorticoids. Systemic glucocorticoids are taken either orally or with an injection. "Both systemic and inhaled glucocorticoid use are associated with decreased white matter integrity and limited changes in [gray matter volume]," researchers wrote. White matter plays a role in neuronal connectivity and brain signaling, they added.

Question: briefly summarize the study method, place, sample size, and finding. Give your opinion about the validity of the published findings

Answer :

the findings of the study appear to be valid. The study had a significant sample size, and the findings were the product of a cross-sectional research that was meticulously conducted.

A new study was published in The BMJ that discovered a correlation between systemic and inhaled glucocorticoids medications that are commonly used for asthma and chronic obstructive pulmonary disease (COPD), as well as structural and volume changes in brain gray and white matter.

The results of the cross-sectional study were drawn from 779 individuals who took the medications and 24,106 controls enrolled in the UK Biobank between 2006 and 2010.

The biobank included 222 patients who used systemic glucocorticoids and 557 who used inhaled glucocorticoids. Systemic glucocorticoids are taken orally or via injection.

According to researchers, "both systemic and inhaled glucocorticoid use are associated with decreased white matter integrity and limited changes in [gray matter volume]." The study was conducted in the United Kingdom over the course of four years.

The participants of the study were 779 individuals who took systemic and inhaled glucocorticoids and 24,106 control subjects. The study concluded that the use of glucocorticoids, whether inhaled or systemic, is related to reduced brain matter. It's uncertain whether the reduced brain matter is caused by the glucocorticoids or by other variables.

Overall, the findings of the study appear to be valid. The study had a significant sample size, and the findings were the product of a cross-sectional research that was meticulously conducted.

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