Answer :

Bactrim should not be used during pregnancy, particularly during the first trimester and near the end of pregnancy, due to the potential risks it poses to the developing fetus and newborn.

Bactrim, a combination of sulfamethoxazole and trimethoprim, is an antibiotic commonly used to treat various bacterial infections. However, it is generally advised not to use Bactrim during pregnancy, especially during the first trimester and near the end of pregnancy.

The primary reason for avoiding Bactrim in pregnancy is the potential risks it poses to the developing fetus. Sulfonamides, the class of drugs to which sulfamethoxazole belongs, have been associated with an increased risk of congenital abnormalities, such as neural tube defects, heart defects, and oral clefts. The risks are particularly high during the first trimester, which is a crucial period for organ development in the fetus.

Additionally, using Bactrim close to the delivery date can increase the risk of jaundice and kernicterus, a rare but serious form of brain damage, in the newborn. These risks are mainly associated with the drug's ability to displace bilirubin from its binding sites, leading to elevated levels of free bilirubin in the blood.

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