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The drug morphine has a high first-pass metabolism. What change in the dosage of morphine would have to be made if the drug were to be administered to an elderly patient?

A. Increase the dosage
B. Decrease the dosage
C. No change in dosage is needed
D. Administer a different drug

Answer :

Final answer:

Given morphine's high first-pass metabolism and the typically reduced liver and kidney function in elderly patients, likely, the dosage would need to be decreased when administering morphine to an elderly patient to minimize the risk of side effects.

Explanation:

The drug morphine is known to have a high first-pass metabolism. This means that a significant portion of the drug is metabolized or 'broken down' during its first pass through the liver before it reaches systemic circulation. When administering medications such as this, patient characteristics, including age and organ function, must be considered. When it comes to elderly patients, they generally have reduced liver and kidney functions which can lead to reduced metabolism and clearance of the drug, consequently, increasing drug levels in the body that may lead to toxicity. Therefore, in the case of morphine, the dosage would likely have to be decreased (Option b) for an elderly patient to minimize the risk of side effects.

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