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If two patients, each weighing 100 lb, were given the drug amikacin sulfate, one at a regimen of 7.5 mg/kg every 12 hours and the other at 5 mg/kg every 8 hours, what is the difference in the total quantity of drug administered over a 24-hour period?

A. 125 mg per day
B. None
C. 250 mg per day
D. 75 mg per day

Answer :

The difference in the total quantity of drug administered over a 24-hour period between the two patients is 0 mg/day.

B. none

How to find the difference in the total quantity

Calculate the total daily dose for each patient:

Patient 1 (7.5 mg/kg q 12 hrs): 7.5 mg/kg x 100 lb = 750 mg every 12 hours

Patient 2 (5 mg/kg q 8 hrs): 5 mg/kg x 100 lb = 500 mg every 8 hours

Determine how many times each patient receives the drug in a 24-hour period:

Patient 1: 24 hours / 12 hours per dose = 2 doses per day

Patient 2: 24 hours / 8 hours per dose = 3 doses per day

Calculate the total daily dose for each patient:

Patient 1: 2 doses/day x 750 mg/dose = 1500 mg/day

Patient 2: 3 doses/day x 500 mg/dose = 1500 mg/day

Find the difference in the total quantity of drug administered:

Patient 1: 1500 mg/day

Patient 2: 1500 mg/day

The difference in the total quantity of drug administered over a 24-hour period between the two patients is 0 mg/day.

So, the correct answer is B. None.

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