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Which of the following is an expected side effect of sunitinib?

A. Peripheral vascular disease
B. Left ventricular dysfunction
C. Gastrointestinal perforation
D. Peripheral neuropathy

Answer :

B Left ventricular dysfunction is an expected side effect of sunitinib.

Sunitinib, a tyrosine kinase inhibitor used in the treatment of various cancers like renal cell carcinoma and gastrointestinal stromal tumors, has known cardiovascular side effects, with left ventricular dysfunction being one of the more significant ones.

This drug can impair cardiac function by causing myocardial cell damage, leading to reduced ejection fraction and, in some cases, heart failure. Monitoring cardiac function is essential during treatment, as left ventricular dysfunction may develop even in patients without preexisting heart conditions.

Sunitinib can also cause hypertension, which may further strain the heart, contributing to left ventricular dysfunction over time. Management involves regular monitoring of blood pressure and cardiac function, with dose adjustments or discontinuation if significant cardiac issues arise.

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Final answer:

Gastrointestinal perforation is an expected side effect of sunitinib, a medication used to treat certain types of cancer. Therefore, the correct answer is C. Gastrointestinal perforation.

Explanation:

The expected side effect of sunitinib that is listed among the options is Gastrointestinal perforation. Sunitinib is a medication used to treat certain types of cancer, but it can have several side effects. While peripheral vascular disease, left ventricular dysfunction, and peripheral neuropathy can be side effects of sunitinib, gastrointestinal perforation is listed as a specific expected side effect.

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