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Answer :
Final answer:
A reasonable time to measure the steady-state level of a drug with an 8-hour half-life, dosed twice daily, is after 4 to 5 half-lives have passed, making Wednesday at 14:00 hours the most appropriate time.
Explanation:
When considering the appropriate time to measure the steady-state level of a drug with an 8-hour half-life that is dosed twice daily, one must account for the time it takes to reach steady state. Typically, steady state is achieved after approximately 4 to 5 half-lives. In this scenario, the drug was started on Monday at 14:00 hours, and given the drug's half-life, a reasonable time to order a steady-state drug level would be after at least 4 to 5 half-lives have passed. This would put the reasonable time to measure the steady state around Wednesday at 14:00 hours (Option c), after 48 hours (6 half-lives) have elapsed.
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