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The recommended initial once-a-day dose of the neurologic drug divalproex sodium is 25 mg/kg/day, to be increased as indicated to an absolute maximum dose of 60 mg/kg/day. Calculate these quantities for a 182-lb patient.

Answer :

Final answer:

The initial dosage calculation of divalproex sodium for a 182 lb (82.55 kg) patient is approximated to be 2064 mg/day while the absolute maximum dosage of the medicine amounts to around 4953 mg/day.

Explanation:

The question pertains to the dosage calculation of the neurologic drug divalproex sodium for a patient weighing 182 lbs. What should be specified here is the conversion of lbs to kg, as the dosage is given in mg/kg/day. Given that 1 lb equals approximately 0.4536 kg, a 182 lb patient weighs about 82.55 kg.

From there, we calculate the initial and maximum doses of the drug. A 25 mg/kg/day initial dosage for an 82.55 kg patient would be approximately 2064 mg/day. For the maximum dosage of 60 mg/kg/day, the calculation would yield a value of approximately 4953 mg/day.

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