Answer :

The extreme itching associated with Sarcoptes scabiei or scabies is caused by the mite's burrowing into the skin and laying eggs. The mite's burrowing and waste products trigger an allergic reaction leading to intense itchiness and a red rash.

The extreme pruritus, or itching, associated with Sarcoptes scabiei infestation, often referred to as scabies, is primarily caused by the mite burrowing into the skin to lay eggs. The female mite creates tunnels in the stratum corneum, the outermost layer of the skin, where she deposits her eggs. Here, the eggs mature into larvae and move to the skin surface, causing intense itching and a red rash due to the body's immune response.

Further exacerbating the itchiness, the mite's burrowing produces waste products, which also cause an allergic reaction. In other words, it's the body's immune reaction to these mite-infested burrows and mite waste that cause the intense itchiness associated with scabies.

Note that while the itchiness might initially be limited to the site of mite infestation, it can become generalized over the entire body as the infestation persists and the body's immune reaction intensifies. Because Sarcoptes scabiei mites are highly contagious, it's crucial to seek treatment immediately to limit the spread of the mites.

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