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A 60-year-old woman is evaluated for new-onset hypertension. Her medical history is significant for metastatic cervical cancer, for which she began chemotherapy 2 months ago. She has no history of hypertension. Her medications are bevacizumab, cisplatin, paclitaxel, dexamethasone, promethazine, and ranitidine. On physical examination, her temperature is normal, blood pressure is 172/106 mm Hg, pulse rate is 82/min, and respiration rate is 18/min. The remainder of the examination is unremarkable.

Which of the following medications is the most likely cause of this patient's hypertension?

1) Bevacizumab
2) Cisplatin
3) Dexamethasone
4) Paclitaxel

Answer :

Final answer:

Bevacizumab is the most likely cause of the patient's hypertension.

Explanation:

The most likely cause of the patient's hypertension is bevacizumab, a medication used for cancer treatment. Bevacizumab is known to increase the risk of hypertension as a side effect. It works by inhibiting the growth of new blood vessels, which can lead to increased blood pressure. The patient in this question, a 60-year-old woman with metastatic cervical cancer undergoing chemotherapy, has developed new-onset hypertension. Out of the medications she is currently taking, Bevacizumab is likely responsible for this development. Bevacizumab is known to cause hypertension as a side effect. It is an anti-angiogenic drug, which works by inhibiting the growth of new blood vessels. However, it also has an effect on the existing blood vessels, causing them to constrict which can lead to an increase in blood pressure. This strong medically relevant fact establishes bevacizumab as the most likely cause for the woman's sudden hypertension.

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