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Answer :
Final answer:
The Classical pathway is the complement activation pathway that directly cooperates with the adaptive immune system. It relies on antibody production and forms an antibody-antigen complex to activate the first protein in the complement cascade, the C1 complex. Other pathways, such as the Alternative and Lectin pathways, differ in their mechanisms of initiation. The correct option is a.
Explanation:
The complement activation pathway that directly cooperates with the adaptive immune system is the Classical pathway. This pathway depends on the production of antibodies by the specific adaptive immune defenses.
In this process, a specific antibody binds to the pathogen to form an antibody-antigen complex, activating the first protein in the complement cascade, called the C1 complex. This classical pathway subsequently recruits and activates the remaining complement proteins in a cascading sequence.
The other pathways mentioned, the Alternative pathway and the Lectin pathway, differ in their initiation. The alternative pathway gets triggered spontaneously without antibody activation, while the lectin pathway initiates upon the binding of mannose-binding lectin to carbohydrates on the microbial surface.
Hence, Option a is correct.
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