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Which of the following pathways is the major way in which alcohol is metabolized?

A. pyruvate dehydrogenase pathway
B. alcohol dehydrogenase pathway
C. ethanol dehydrogenase pathway
D. lactate dehydrogenase pathway

Answer :

The major way in which alcohol is metabolized is through the B. alcohol dehydrogenase pathway. This pathway involves the enzyme alcohol dehydrogenase, which converts alcohol (ethanol) into acetaldehyde, a toxic substance. Acetaldehyde is then further metabolized by another enzyme called aldehyde dehydrogenase, which converts it into acetate, a less harmful substance that can be broken down into water and carbon dioxide.

Multiple enzymatic pathways, including alcohol dehydrogenase (ADH), cytochrome P4502E1 (CYP2E1), and catalase, are the primary means by which inebriated alcohol is eliminated through metabolic degradation.

The beta subunit of class I alcohol dehydrogenase (ADH), an enzyme that catalyzes the rate-limiting step for ethanol metabolism, is encoded by the alcohol dehydrogenase 1B, beta polypeptide (ADH1B) gene (also known as ADH2).

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