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Where do silent mutations occur?

Answer :

Silent mutations occur when the change of the DNA sequence within a protein-coding portion of a gene does not affect the sequence of amino acids that make up the protein.

This change typically takes place at the third position of the codon also known as the wobble position. A stretch of very highly conserved silent mutation sites occurs, on average, once every 10,000 to 15,000 nucleotides of gene sequence. We estimate that between 5 and 10 percent of human genes contain at least one region where silent mutations could be harmful.

A thymine is actually changed to a cytosine at the DNA level by the silent mutation. This mutation may have resulted through a replication error in the DNA or from a type of repair carried out after the DNA was damaged.

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