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Answer :
Receptor tyrosine kinases (RTKs) are a family of cell surface receptors that play essential roles in cellular processes, including cell growth, differentiation, and metabolism. The pathways that are activated by receptor tyrosine kinases are Ras and pi3k. The correct options are a and b.
Upon ligand binding, RTKs undergo dimerization and autophosphorylation, which leads to the activation of downstream signaling pathways. The correct pathways activated by receptor tyrosine kinases include:
a. Ras - The Ras pathway is activated when RTKs recruit adaptor proteins, such as Grb2, which in turn bind to guanine nucleotide exchange factors (GEFs), like SOS. This process leads to the exchange of GDP for GTP on Ras, resulting in its activation and downstream signaling events.
b. PI3K - The phosphoinositide 3-kinase (PI3K) pathway is also activated by RTKs. Upon receptor activation, PI3K binds to phosphorylated tyrosine residues on the receptor, leading to its activation. Activated PI3K then converts PIP2 to PIP3, which in turn activates Akt, a crucial kinase involved in cell survival, growth, and proliferation.
c. Wnt - This pathway is NOT activated by receptor tyrosine kinases. The Wnt signaling pathway is primarily initiated by the binding of Wnt ligands to Frizzled receptors, which are distinct from RTKs.
d. TGFb - The transforming growth factor-beta (TGFb) signaling pathway is also NOT activated by receptor tyrosine kinases. TGFb signals through serine/threonine kinase receptors, which are structurally and functionally different from RTKs.
In conclusion, the pathways activated by receptor tyrosine kinases include Ras (a) and PI3K (b).
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