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Which of the following proteins combine to form the Microprocessor complex used to produce active miRNA?

A. RNA polymerase
B. Dicer and Argonaute
C. Drosha and DGCR8
D. RNA helicase

Answer :

Final answer:

Drosha and DGCR8 proteins form the Microprocessor complex that is responsible for the initial processing of primary miRNAs (pri-miRNAs) into precursor miRNAs (pre-miRNAs) in the nucleus. These pre-miRNAs are then transferred to the cytoplasm where they are further processed into mature miRNAs to regulate gene expression.

Explanation:

In the process of producing active microRNAs (miRNA), the proteins that combine to form the Microprocessor complex are Drosha and DGCR8. In the nucleus, these two proteins work together to convert primary miRNAs (pri-miRNAs) to precursor miRNAs (pre-miRNAs). Specifically, Drosha cleaves the pri-miRNA into a pre-miRNA while DGCR8 helps in recognizing and binding the pri-miRNA. These pre-miRNAs are then transported to the cytoplasm, where another protein complex that includes Dicer further processes them into mature miRNAs, ready to regulate gene expression.

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