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Answer :
Final answer:
Application of glutamate to a silent synapse where the resting membrane potential is -80mV leads to sodium influx through glutamate receptors.
Explanation:
When glutamate is applied to a silent synapse with a resting membrane potential starting at -80mV, the neuron's membrane potential is likely to change. Glutamate receptors are non-selective cation channels that allow the flow of both sodium and potassium ions.
Given that the reversal potential for the glutamate receptor is approximately 0 mV, more sodium flows into the cell than potassium flows out, especially when the resting membrane potential is quite negative, such as -80mV.
This influx of sodium ions results in a depolarization of the cell membrane. When sodium ions enter the cell, the membrane potential becomes less negative (moves toward zero), which, if sufficient, may initiate an action potential.
If the membrane potential were to reach the reversal potential of the glutamate receptor, the electrochemical gradients acting on sodium and potassium would balance, resulting in no overall change in ion flow in either direction and the membrane potential would stabilize at 0 mV.
However, this is typically not the case, as continued entry of sodium leads to depolarization and potentially the firing of the neuron.
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