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The clamp loader that loads PCNA onto DNA is called _______ and is analogous to the E. coli DNA polymerase III clamp loader complex.

A. RFC
B. KFC
C. NBC
D. TLC
E. SEC

Answer :

Final answer:

The clamp loader that loads PCNA onto DNA is called Replication Factor C (RFC), and is analogous to the E. coli DNA polymerase III clamp loader complex. These protein complexes assist DNA polymerases in copying genomes efficiently and accurately.

Explanation:

The clamp loader that loads PCNA onto DNA is referred to as RFC (Replication Factor C). Analogous to the E. coli DNA polymerase III clamp loader complex, this protein complex plays an integral role in DNA replication within eukaryotic cells. The primary function of the RFC is to load on the PCNA (Proliferating cell nuclear antigen), otherwise known as the sliding clamp, on the DNA template strand. This sliding clamp provides a strong grip for the DNA polymerase onto the DNA, thereby enhancing its processivity during replication. Essentially.

The RFC and PCNA work together to ensure the smooth operation of the replication machinery, namely the DNA polymerase. The RFC performs a similar function in eukaryotes as the DNA polymerase III clamp loader complex does in E.coli. This E.coli enzyme complex functions in the process of DNA replication by loading the beta-clamp onto the DNA, thereby aiding the DNA polymerase III's rapid and accurate duplication of the bacterial genome.

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