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Sickle cell anemia is caused by a recessive allele with an allele frequency of 0.1 in the general population. What is the expected frequency of unaffected individuals in the population?

Answer :

Final answer:

The expected frequency of unaffected individuals in the population is 0.81, or 81%, as calculated by squaring the non-sickle cell allele frequency.

Explanation:

Sickle cell anemia is a genetic disease caused by a recessive allele. In the scenario you've described, the allele frequency for the sickle cell recessive allele is 0.1. Individuals are unaffected by sickle cell anemia when they are homozygous for the non-sickle cell (dominant) allele. The frequency for this genotype (AA) is calculated by squaring the frequency of the A allele (0.9), as determined by 1 minus frequency of the recessive allele (1-0.1 = 0.9). So, the expected frequency of unaffected individuals in the population is 0.9*0.9 or 0.81, or 81%.

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