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Warfarin is metabolized through which of the following pathways?

1) Renal pathway
2) Hepatic pathway
3) Pulmonary pathway
4) Intestinal pathway

Answer :

Final answer:

Warfarin is metabolized through the hepatic pathway. The correct option is 2) Hepatic pathway.

Explanation:

Warfarin is metabolized through the hepatic pathway. This process involves the liver's microsomal enzymes, which break down medications, including warfarin, into simpler compounds. The liver plays a crucial role in the biotransformation of warfarin, making it more ionized and therefore less lipid-soluble. This transformation prevents the metabolized drug from easily crossing the blood-brain barrier (BBB). After being metabolized, warfarin is primarily excreted from the body through the kidneys (in urine), but other excretion pathways, such as bile and feces, also play a role. This detailed process ensures that warfarin's anticoagulant effects are properly managed and that excessive clotting or bleeding risks are minimized, highlighting the importance of the liver in warfarin metabolism.

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