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A 45-year-old man underwent abdominal CT imaging for evaluation of bloating and constipation. The CT scan shows a 5-cm right adrenal mass with a density of 42 Hounsfield units and absolute contrast washout of 38% at 10 minutes. Testing for pheochromocytoma and subclinical Cushing syndrome was negative. Medical history is otherwise unremarkable, and he takes no medications. On physical examination, vital signs and the remainder of the physical examination are normal.

Which of the following is the most appropriate next step in management?

A. Adrenal biopsy
B. Adrenalectomy
C. Mitotane therapy
D. Repeat CT at 6 months

Answer :

Final answer:

The most appropriate next step in management for a 45-year-old man with a 5-cm right adrenal mass and negative testing for pheochromocytoma and subclinical Cushing syndrome is adrenalectomy.

Explanation:

The most appropriate next step in management for a 45-year-old man with a 5-cm right adrenal mass and negative testing for pheochromocytoma and subclinical Cushing syndrome is Adrenalectomy. Adrenalectomy involves surgical removal of the adrenal gland and is the preferred treatment for adrenal tumors larger than 4 cm that cause clinical symptoms, such as bloating and constipation. In this case, since the CT scan shows a 5-cm mass and the patient is symptomatic, adrenalectomy would be the most appropriate next step to further evaluate and manage the mass.

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