We appreciate your visit to How does a ketone react with a Grignard reagent to form a tertiary alcohol How does a nitrile react with a Grignard reagent to form. This page offers clear insights and highlights the essential aspects of the topic. Our goal is to provide a helpful and engaging learning experience. Explore the content and find the answers you need!
Answer :
Final answer:
Grignard reagents react with ketones to produce tertiary alcohols by adding two alkyl groups. They react with nitriles to form ketones by adding one alkyl group and hydrolyzing the imine salt intermediate. Preparation of an aldehyde from an N,N-dialkylalkanamide requires controlled conditions.
Explanation:
Reaction of Grignard Reagents with Ketones and Nitriles
Grignard reagents are well-known for their ability to form new carbon-carbon bonds. When a Grignard reagent reacts with a ketone, it adds to the carbonyl carbon to form a new C-C bond, creating an alkoxide intermediate. After the subsequent acid work-up, this intermediate is protonated to produce a tertiary alcohol. The final product is a tertiary alcohol because two alkyl groups are introduced from the Grignard reagent, and the ketone already carries one alkyl group (assuming this is a carbon group).
Conversely, when a Grignard reagent reacts with a nitrile, the nucleophilic carbon of the Grignard adds to the electrophilic carbon in the nitrile forming an imine salt, which upon hydrolysis gives a ketone. This is because only one alkyl group is introduced from the Grignard reagent.
For the preparation of an aldehyde from an N,N-dialkylalkanamide, a careful choice of Grignard reagent and control of conditions must be made to ensure that only one equivalent of Grignard is added, stopping the reaction at the aldehyde stage before further addition occurs.
Thanks for taking the time to read How does a ketone react with a Grignard reagent to form a tertiary alcohol How does a nitrile react with a Grignard reagent to form. We hope the insights shared have been valuable and enhanced your understanding of the topic. Don�t hesitate to browse our website for more informative and engaging content!
- Why do Businesses Exist Why does Starbucks Exist What Service does Starbucks Provide Really what is their product.
- The pattern of numbers below is an arithmetic sequence tex 14 24 34 44 54 ldots tex Which statement describes the recursive function used to..
- Morgan felt the need to streamline Edison Electric What changes did Morgan make.
Rewritten by : Barada
