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Answer :
A bacterial strain exhibiting a unique RNA polymerase structure would most likely inhibit the activity of the rifampin antibiotic.
What is RNA polymerase?
RNA polymerase is an enzyme that participates in DNA transcription, which is the procedure of transcribing DNA sequences into RNA sequences. RNA polymerase, like other polymerases, creates polymers from a monomer. RNA polymerase catalyzes the addition of nucleotides to the 3'-end of a growing RNA chain by reading the template DNA strand, therefore synthesizing a complementary RNA strand according to the base-pairing rules.
Antibiotics and RNA polymerase structureBacteria have various mechanisms of resistance to antibiotics, which include changing the target of the antibiotic, reducing antibiotic influx or increasing antibiotic efflux, and altering the antibiotic. Rifampin, on the other hand, has a unique mechanism of action. Rifampin is a bactericidal antibiotic that targets RNA polymerase, a bacterial enzyme responsible for gene transcription that converts DNA into mRNA.
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