High School

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A doctor has prescribed 60 g of the following Dithranol Ointment:

- Dithranol: 100 mg
- White Soft Paraffin: 99.9 g

Show how you would make the ointment, given the minimum weighable quantity in the lab is 100 mg (meaning we cannot weigh below 100 mg on the scale accurately).

Answer :

To prepare 60g of the Dithranol Ointment with a minimum weighable quantity of 100mg, you would use a technique called "dilution" or "geometric dilution" to accurately weigh and mix the small amount of Dithranol with the White Soft Paraffin.

1. Step 1: Weigh the Dithranol

  • Since the minimum weighable quantity is 100mg, you'll weigh out 100mg of Dithranol, which is 10 times the required amount for the ointment (you need 10mg of Dithranol per gram of ointment, so for 60g, you'd need 600mg).

2. Step 2: Dilute the Dithranol

  • To get the required concentration, you'll need to dilute the 100mg of Dithranol to match the required 60g of the ointment. Mix the 100mg of Dithranol with 9.9g of White Soft Paraffin to make a total of 10g of a 1% Dithranol mixture. This is the same concentration as your final ointment.

3. Step 3: Prepare the Final Mixture

  • Now, take 6g of this 1% Dithranol mixture. This 6g will contain the required 60mg of Dithranol.
  • Mix this 6g of the 1% Dithranol mixture with the remaining 54g of White Soft Paraffin.

4. Step 4: Homogenize the Ointment

  • Thoroughly mix the final 60g ointment to ensure an even distribution of the Dithranol throughout the ointment.

This process ensures that the Dithranol is accurately measured and evenly distributed within the White Soft Paraffin, despite the limitations of the scale's minimum weighable quantity.

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