Middle School

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How did you create a silent mutation?

Explain by giving the code for the triplet where you made your substitution, both before and after the mutation.

Answer :

Explanation:

Silent mutations are mutations in DNA that do not have an observable effect on the organism's phenotype. They are a specific type of neutral mutation. The phrase silent mutation is often used interchangeably with the phrase synonymous mutation; however, synonymous mutations are not always silent, nor vice versa.

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Rewritten by : Barada

Silent mutations involve changes in the DNA sequence that do not affect the amino acid sequence of a protein. For example, changing the TCT codon for serine to TCC also results in serine, due to the redundancy of the genetic code. Such mutations are only detectable through DNA sequencing.

Silent mutations refer to changes in the nucleotide sequence of DNA that do not result in changes to the amino acid sequence of the resulting protein. This occurs due to the redundancy in the genetic code, where different codons can code for the same amino acid.

For example, consider the codon TCT, which codes for the amino acid serine. If a point mutation changes the third base from TCT to TCC, TCA, or TCG, it will still code for serine, creating a silent mutation. Here is the specific substitution:

  • Before mutation: TCT (codes for serine)
  • After mutation: TCC (also codes for serine)

Since a silent mutation does not alter the protein product, it can only be detected through DNA sequencing.