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Answer :
Final answer:
The most reasonable time to order a steady-state drug level for a drug with an 8-hour half-life, dosed twice daily, is Wednesday at 06:00 hours. This allows for 5 half-lives to pass and includes two full days of dosing, ensuring a steady-state concentration.
Explanation:
To determine a reasonable time to order a steady-state drug level for a drug with an 8-hour half-life that is dosed twice daily, one must calculate how many half-lives are necessary to reach steady state. Typically, it takes about 4 to 5 half-lives for a drug to reach steady state. Since the medication was started at 14:00 on Monday, and it is dosed twice daily with an 8-hour half-life, the earliest you would expect to reach steady state would be after 4 to 5 doses.
Counting from the initial dose, steady state would theoretically be approached after 32 to 40 hours (which is 4 to 5 half-lives). Given that the drug is started at 14:00 on Monday, 32 hours later would be 22:00 on Tuesday, and 40 hours later would be 06:00 on Wednesday. Thus, Wednesday at 06:00 hours (option c) would be the most reasonable time to order a steady-state drug level, allowing for at least 5 half-lives to have passed and two full days of dosing.
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