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An antiarrhythmic drug follows one compartment PK model. Its therapeutic windows is known as 4−9mg/L. A patient weighing 154lb. was rushed to an emergency room due to tachyarrythmia and an IV bolus dose of the drug needs to be calculated in order to produce the initial plamsa level of 9mg/L. The plasma half-life of the drug is known to be 2 h and the volume of distribution is known to be 2 L/kg. The bolus dose is ?

Answer :

Final answer:

To calculate the bolus dose of the antiarrhythmic drug, use the one compartment PK model and plasma half-life. Divide the desired concentration by the volume of distribution, calculate the time to decrease to the therapeutic window, and use the clearance rate to determine the bolus dose.

Explanation:

To calculate the bolus dose of the antiarrhythmic drug, we can use the concept of the one compartment PK model. The initial plasma level of 9mg/L can be achieved by dividing the desired concentration by the volume of distribution. Then, we can use the plasma half-life to calculate how long it takes for the drug to decrease to the therapeutic window. Finally, we multiply the half-life by the natural log of the ratio of the desired concentration to the therapeutic window, and divide it by the clearance rate to calculate the bolus dose.

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