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Outside the body, what pathway initiates blood clotting?

A) Extrinsic pathway
B) Intrinsic pathway
C) Common pathway
D) Fibrinolysis pathway

Answer :

Final answer:

The A) extrinsic pathway is responsible for initiating blood clotting outside the body and leads into the common pathway, creating a stable blood clot.

Explanation:

The pathway that initiates blood clotting outside the body is the A) extrinsic pathway.

The extrinsic pathway, also known as the tissue factor pathway, is triggered when damage occurs to the surrounding tissues, such as in a traumatic injury.

This pathway is quicker and more direct compared to the intrinsic pathway. When damage takes place, cells extrinsic to the bloodstream release factor III, or thromboplastin.

Sequentially, with the presence of calcium ions (Ca²⁺), the pathway leads to the activation of factor VII, which then activates factor X, leading into the common pathway.

The common pathway involves the conversion of prothrombin into the active enzyme thrombin, which then transforms fibrinogen into insoluble fibrin strands to form a stable clot.

Factor XIII then stabilizes the fibrin clot, completing the process of coagulation.

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