The following target molecule can be made via a Grignard Reaction. Show two sets of carbonyl and Grignard reagents that would result in the product when reacted together.

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13-08-2023
Chemistry

High School

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The following target molecule can be made via a Grignard Reaction. Show two sets of carbonyl and Grignard reagents that would result in the product when reacted together.

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vignesh67 vignesh67 · Answer 1 · 2023-10-28T06:06:45-04:00

To synthesize a target molecule using a Grignard reaction, one can combine an aldehyde or a ketone with a Grignard reagent. Two example sets might involve reacting R1CHO with R2MgX or R3CO with R4MgX to form an alcohol with a new carbon-carbon bond.

Show Two Sets of Synthesis Reactants using Grignard Reaction

To synthesize a molecule using a Grignard reaction, one needs to start with a suitable carbonyl compound and a Grignard reagent. The nature of the desired final product determines which specific carbonyl compound and Grignard reagent are required.

The Grignard reagent is typically synthesized by reacting an alkyl, vinyl, or aryl halide (RX) with magnesium metal in ether. For example:
RMgX

A carbonyl compound such as an aldehyde or ketone will then react with the Grignard reagent to produce an alcohol. Here are two example sets of reactants that could form a given target molecule:

Set 1: R1CHO (an aldehyde) + R2MgX (a Grignard reagent)

Set 2: R3CO (a ketone) + R4MgX (a different Grignard reagent)

The product of the reaction will have a new carbon-carbon bond formed between the alkyl group (R2 or R4) of the Grignard reagent and the carbonyl carbon atom, resulting in a secondary or tertiary alcohol.