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Answer :
Final answer:
The receptor is auto-phosphorylated upon activation in the JAK-STAT signaling pathway. Upon cytokines or growth factors bind to the receptor, it results in its auto-phosphorylation by Janus Kinase (JAK) which further impacts downstream molecules.
Explanation:
The signaling pathway where the receptor is auto-phosphorylated upon activation is the JAK-STAT pathway (Option C).
In this pathway, the binding of cytokines or growth factors to their respective receptors results in the activation of the Janus Kinase (JAK) associated with the receptor. The activated JAK then auto-phosphorylates itself as well as the receptor. This auto-phosphorylation provides a binding site for downstream signaling molecules, particularly the Signal Transducer and Activator of Transcription (STAT) proteins. The STAT proteins, once bound to the phosphorylated receptor, themselves get phosphorylated by the activated JAK.
After getting phosphorylated, STAT proteins dimerize (form pairs) and move to the nucleus where they act as transcriptional activators influencing expression of certain genes.
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