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Use retrosynthetic analysis to suggest a way to synthesize 3-hexanol using the Grignard reaction. Identify the aldehyde and Grignard reagents needed.

Answer :

To synthesize 3-hexanol using the Grignard reaction, we need to perform retrosynthetic analysis and work backwards. 3-hexanol can be synthesized by the reduction of 3-hexanal. Therefore, we need to identify the aldehyde required for this reaction. The aldehyde required for the synthesis of 3-hexanol can be obtained from the cleavage of the C-C bond present in 2-methylpentane.

This will give us 2-methylpentanal, which can then be used as a starting material. To form the Grignard reagent, we need magnesium and the halogenated compound. Therefore, we need to react magnesium with 2-bromo-3-methylpentane to obtain the Grignard reagent required for the reaction. In summary, to synthesize 3-hexanol using the Grignard reaction, we need 2-methylpentanal and the Grignard reagent formed from the reaction between magnesium and 2-bromo-3-methylpentane.


To synthesize 3-hexanol using the Grignard reaction and retrosynthetic analysis, we first identify the target molecule's functional group. In this case, it is an alcohol. We then perform a disconnection at the carbon-oxygen bond, yielding an aldehyde and a Grignard reagent. The aldehyde needed for the synthesis of 3-hexanol is butanal (C4H8O) and the Grignard reagent needed is ethylmagnesium bromide (C2H5MgBr). The reaction between butanal and ethylmagnesium bromide will yield 3-hexanol, as the Grignard reagent will attack the carbonyl group of the aldehyde, resulting in the formation of the desired alcohol.

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