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Answer :
Darkened skin is a symptom of Addison’s disease due to excessive ACTH secretion, which stimulates melanin production.
One symptom of Addison’s disease is darkened skin. This occurs because the body's adrenal glands produce insufficient amounts of cortisol. In response to low cortisol levels, the pituitary gland secretes excessive amounts of adrenocorticotropic hormone (ACTH) to stimulate cortisol production. ACTH is structurally similar to melanocyte-stimulating hormone (MSH), which causes increased melanin production and leads to hyperpigmentation or darkened skin.
Other symptoms of Addison's disease include low blood pressure, fatigue, and salt cravings, and it is generally treated with hormone replacement therapy. This happens because of insufficient cortisol production by the adrenal glands. Hormone replacement therapy is the common treatment.
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Answer:
adrenal glands
Explanation:
if the adrenal glands do not produce enough hormones the HPA axis makes more POMC. this can lead to increased melanin in the skin forming dark or discolored patches that are accompanied by Addison's disease.
