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Answer :
Final answer:
The maturational pathway a stem cell follows to mature into a platelet involves commitment, multiplication, differentiation, and maturation, showcasing the intricate process of hematopoiesis in producing essential blood components. The correct order is a., b., d. and c.
Explanation:
The question "Which is the maturational pathway a stem cell takes when it differentiates and matures into a platelet?" concerns the process of hematopoiesis, which is a crucial aspect of Biology, specifically within the field of cellular biology and developmental biology. The developmental pathway a stem cell follows to eventually become a mature platelet encapsulates a series of structured steps, starting from its initial state as a multipotent hematopoietic stem cell within the bone marrow.
- Commitment: This is the initial phase where the stem cell commits to a specific lineage. In the context of platelet formation, hematopoietic stem cells (HSCs) commit to the megakaryocyte lineage, which will eventually form platelets.
- Multiplication: Following commitment, the cells proliferate to increase in number. This step is crucial for ensuring that there are enough progenitor cells available to mature into platelets.
- Differentiation: In this phase, committed progenitors start to differentiate into more specialized cells. For platelet formation, this involves the differentiation of megakaryocyte progenitor cells into mature megakaryocytes.
- Maturation: Finally, the mature megakaryocytes undergo further changes, leading to the release of platelets into the bloodstream. This stage includes the process of cytoplasmic fragmentation where the megakaryocytes break up into thousands of platelets.
Understanding the complexities of hematopoiesis and the specific pathways of cell differentiation and maturation is fundamental in comprehending how the human body replenishes its blood cells, including platelets, which are essential for clotting and wound healing processes.
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