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A. A darkening and thickening of the skin, typically on the back/sides of the neck or the axillae; indicative of insulin resistance

Answer :

Final answer:

Acanthosis Nigricans is a condition characterized by a darkening and thickening of the skin.

Explanation:

The darkening and thickening of the skin, typically on the back/sides of the neck, underarms, or axillae is referred to as Acanthosis Nigricans. It is often associated with insulin resistance, which is a condition where the body's cells can't effectively use the insulin it produces and hence a common sign in diabetes. In some cases, it can also be indicative of certain cancers or hormonal disorders.

The skin changes manifest as a dark, thick, and sometimes velvety skin patch that may be itchy. It's most commonly found in areas of the body with many folds, such as the armpits, groin, and neck. The process occurs when insulin spills over from the bloodstream into the skin due to chronic or extreme insulin resistance. When the insulin interacts with skin cells, it forces them to proliferate abnormally, resulting in physical changes to the skin.

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